Loss of human leucocyte antigen class I and gain of class II expression are early events in carcinogenesis: Clues from a study of Barrett's oesophagus

Loss of human leucocyte antigen class I and gain of class II expression are early events in carcinogenesis: Clues from a study of Barrett's oesophagus

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Background: Human leucocyte antigen (HLA) expression is altered in oesophageal carcinomas compared with normal tissue. It is unclear, however, whether this phenotype precedes malignant transformation or results as a consequence of it. Aim: To investigate HLA class I and II expression in Barrett'...

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Bibliographic Details
Main Authors: Ackroyd, R. (Author), Ho, J.J (Author), Karim, N. (Author), Kutty, M.K (Author), Mohan, C. (Author), Rajendra, S. (Author)
Format: Article
Language:English
Subjects:
adult
Adult
aged
Aged
antigen expression
article
Barrett esophagus
Barrett Esophagus
carcinogenesis
Case-Control Studies
Cell Transformation, Neoplastic
controlled study
Disease Progression
down regulation
dysplasia
endoscopy
Esophageal Neoplasms
female
Female
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
histopathology
HLA antigen
HLA antigen class 1
HLA antigen class 2
HLA DP antigen
HLA DQ antigen
HLA DR antigen
HLA system
human
human tissue
Humans
Immunoenzyme Techniques
immunohistochemistry
intestine metaplasia
major clinical study
major histocompatibility antigen class 1
major histocompatibility antigen class 2
major histocompatibility complex
male
Male
malignant transformation
Middle Aged
monoclonal antibody
nonsteroid antiinflammatory agent
phenotype
Precancerous Conditions
priority journal
squamous cell
upregulation
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