Gas Chromatography-Mass Spectrometry Coupled with Multivariate Statistical Analysis to Identify the Alpha Glucosidase Inhibitors from Flesh of Salacca zalacca Fruits and Their Molecular Docking Studies

Gas Chromatography-Mass Spectrometry Coupled with Multivariate Statistical Analysis to Identify the Alpha Glucosidase Inhibitors from Flesh of Salacca zalacca Fruits and Their Molecular Docking Studies

Fruit of salak (Salaaca zalacca) is traditionally used and commercialized as an antidiabetic agent. However, scientific evidence to prove this folk claim is quite lacking. Therefore, this research was aimed to evaluate the α-glucosidase inhibition activity of S. zalacca fruit and identify the bioact...

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Bibliographic Details
Main Authors: Abdullah Alshwyeh, H. (Author), Ali Al-Mekhlafi, N. (Author), Ismail, N.H (Author), Kamisah, Y. (Author), Mediani, A. (Author), Saleh, M.S.M (Author), Siddiqui, M.J (Author)
Format: Article
Language:English
Published: Hindawi Limited 2021
Series:Evidence-based Complementary and Alternative Medicine
Subjects:
alpha glucosidase inhibitor
antidiabetic activity
antidiabetic agent
Article
carbohydrate
controlled study
crystal structure
derivatization
diabetes mellitus
drug potency
fatty acid
flame ionization detection
glucose transport
human
hydrophobicity
IC50
inositol
mass fragmentography
metabolomics
methoxyamine
molecular docking
palmitic acid
partial least squares regression
plant extract
quercetin
Salacca zalacca extract
sitosterol
statistical analysis
stearic acid
sterol
unclassified drug
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