Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer

Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer

Circular RNAs (circRNA) containing retained introns are normally sequestered in the nucleus. Dysregulation of cellular homeostasis can drive their nuclear export, which may be involved in cancer metastasis. However, the mechanism underlying circRNA nuclear export and its role in lymph node (LN) meta...

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Bibliographic Details
Main Authors: An, M. (Author), Chen, C. (Author), Chen, J. (Author), Huang, J. (Author), Kong, Y. (Author), Li, Y. (Author), Lin, T. (Author), Lin, Y. (Author), Luo, Y. (Author), Pang, M. (Author), Yang, J. (Author), Zhang, D. (Author), Zheng, H. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Active Transport, Cell Nucleus
bladder tumor
genetics
human
Humans
lymph node metastasis
Lymphatic Metastasis
metabolism
nucleocytoplasmic transport
pathology
RNA, Circular
Smad7 protein
Smad7 Protein
SMAD7 protein, human
transforming growth factor beta
Transforming Growth Factor beta
Urinary Bladder Neoplasms
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