The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

The phosphoinositide 3-kinase (PI3K) pathway regulates proliferation, survival, and metabolism and is frequently activated across human cancers. A comprehensive elucidation of how this signaling pathway controls transcriptional and cotranscriptional processes could provide new insights into the key...

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Bibliographic Details
Main Authors: Abdel-Wahab, O. (Author), Arruabarrena-Aristorena, A. (Author), Baldino, L. (Author), Blawski, R. (Author), Carmona, J. (Author), Castel, P. (Author), Chandarlapaty, S. (Author), Cocco, E. (Author), Fairchild, L. (Author), Hristidis, V. (Author), Jhaveri, K. (Author), Kittane, S. (Author), Ladewig, E. (Author), Leslie, C. (Author), Michelini, F. (Author), Sallaku, M. (Author), Scaltriti, M. (Author), Toska, E. (Author), Zhang, Y. (Author), Zuniga, A.G (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Breast Neoplasms
breast tumor
carcinogenesis
Carcinogenesis
Cell Line, Tumor
Class I Phosphatidylinositol 3-Kinases
female
Female
genetics
human
Humans
metabolism
pathology
phosphatidylinositol 3 kinase
Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
phosphatidylinositol 4,5 bisphosphate 3 kinase
RNA splicing
RNA Splicing
transcriptome
Transcriptome
tumor cell line
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