Noise Exposure and Distortion Product Otoacoustic Emission Suprathreshold Amplitudes: A Genome-Wide Association Study

Noise Exposure and Distortion Product Otoacoustic Emission Suprathreshold Amplitudes: A Genome-Wide Association Study

Background: Although several candidate-gene association studies have been conducted to investigate noise-induced hearing loss (NIHL) in humans, most are underpowered, unreplicated, and account for only a fraction of the genetic risk. Mouse genome-wide association studies (GWASs) have revolutionized...

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Bibliographic Details
Main Authors: Allayee, H. (Author), Bento, R.F (Author), Crow, A.L (Author), Friedman, R.A (Author), Kasperbauer, G. (Author), Lavinsky, J. (Author), Mendonça, A. (Author), Wang, J. (Author)
Format: Article
Language:English
Published: S. Karger AG 2021
Subjects:
animal
animal experiment
animal model
Animal models
Animals
Article
auditory threshold
Auditory Threshold
chromosome 1
chromosome 15
chromosome 16
chromosome 2
chromosome 3
cochlea
Cochlea
controlled study
distortion product otoacoustic emission
Distortion product otoacoustic emission
DNA microarray
efr3a gene
environmental exposure
expression quantitative trait locus
eya1 gene
female
gene
gene expression
gene frequency
gene linkage disequilibrium
gene locus
gene mapping
gene sequence
genetic risk
genetic susceptibility
genetic variability
genetics
genome-wide association study
Genome-wide association study
Genome-Wide Association Study
genotype
genotyping
Hearing Loss, Noise-Induced
ketamine
male
Mice
mouse
noise
Noise
noise injury
Noise-induced hearing loss
nonhuman
Otoacoustic Emissions, Spontaneous
outer hair cell
pathogenesis
phenotype
population structure
recombinant inbred strain
signal noise ratio
single nucleotide polymorphism
spontaneous otoacoustic emission
xylazine
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