CD4+ T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent

CD4+ T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent

Rationale: Lymphopenia is common in severe coronavirus disease (COVID-19), yet the immune mechanisms are poorly understood. As inflammatory cytokines are increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we hypothesized a role in contributing to reduced T-cell numb...

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Main Authors: Alder, J.K (Author), An, X. (Author), Bhatt, P. (Author), Brown, M.J (Author), Burke, R. (Author), Chen, B.B (Author), Chen, K. (Author), Chen, X. (Author), Das, A. (Author), Deng, E. (Author), Hannan, S.J (Author), Iasella, C.J (Author), Johnson, B. (Author), Kass, D.J (Author), Kilaru, S. (Author), Kiss, J.E (Author), Kitsios, G. (Author), Konstantinidis, I. (Author), Koshy, R. (Author), Lendermon, E.A (Author), Lieber, S.C (Author), Linstrum, K. (Author), Lyons, E.J (Author), McDyer, J.F (Author), McMahon, D.K (Author), McVerry, B.J (Author), Morris, A. (Author), Pilewski, J.M (Author), Popescu, I. (Author), Sanchez, P.G (Author), Saul, M. (Author), Sembrat, J.C (Author), Snyder, M.E (Author), Triulzi, D.J (Author), Wells, A.H (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
CD4+ T cells
COVID-19
lymphopenia
SARS-CoV-2 infection
TNF-α
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