Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm–blast phase

Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm–blast phase

Chronic myeloproliferative neoplasms (MPN) frequently evolve to a blast phase (BP) that is almost uniformly resistant to induction chemotherapy or hypomethylating agents. We explored the functional properties, genomic architecture, and cell of origin of MPN-BP initiating cells (IC) using a serial NS...

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Main Authors: Davis, A. (Author), Farnoud, N. (Author), Hoffman, R. (Author), Hu, C.S (Author), Iancu-Rubin, C. (Author), Kremyanskaya, M. (Author), Lu, M. (Author), Mascarenhas, J. (Author), McGovern, E. (Author), Najfeld, V. (Author), Patel, M. (Author), Petersen, B. (Author), Rampal, R.K (Author), Rossi, M.R (Author), Tripodi, J. (Author), Wang, X. (Author), Weinberg, R.S (Author)
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022
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