Targeting p-AKT/mTOR/MAP kinase signaling, NLRP3 inflammasome and apoptosis by fluvastatin with or without taxifolin mitigates gonadal dysfunction induced by bisphenol-A in male rats

Targeting p-AKT/mTOR/MAP kinase signaling, NLRP3 inflammasome and apoptosis by fluvastatin with or without taxifolin mitigates gonadal dysfunction induced by bisphenol-A in male rats

Bisphenol-A (BPA) is a chemical substance that is widely used in industry for manufacturing of plastic bottles and resins. Recent reports found that BPA may mimic the effects of estrogen to a great manner that might disrupt the normal hormonal balance in the human body. Fluvastatin is an agent used...

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Bibliographic Details
Main Authors: Abd Elmaaboud, M.A (Author), Ali, D.A (Author), Borg, H.M (Author), Kabel, A.M (Author), Salama, S.A (Author)
Format: Article
Language:English
Published: SAGE Publications Ltd 2022
Subjects:
animal
Animals
antioxidant
Antioxidants
apoptosis
Apoptosis
autophagy
Benzhydryl Compounds
benzhydryl derivative
bisphenol-A
cryopyrin
fluindostatin
fluvastatin
Fluvastatin
inflammasome
Inflammasomes
male
Male
metabolism
mitogen activated protein kinase
Mitogen-Activated Protein Kinases
mTOR protein, rat
NLR Family, Pyrin Domain-Containing 3 Protein
Nlrp3 protein, rat
oxidative stress
Oxidative Stress
protein kinase B
Proto-Oncogene Proteins c-akt
quercetin
Quercetin
rat
Rats
target of rapamycin kinase
taxifolin
testis
Testis
TOR Serine-Threonine Kinases
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