Ursolic acid protects against anoxic injury in cardiac microvascular endothelial cells by regulating intercellular adhesion molecule-1 and toll-like receptor 4/MyD88/NF-κB pathway

Ursolic acid protects against anoxic injury in cardiac microvascular endothelial cells by regulating intercellular adhesion molecule-1 and toll-like receptor 4/MyD88/NF-κB pathway

Background: Cardiac microvascular endothelial cells (CMECs) are rapidly damaged after myocardial ischemia or hypoxia. In this study, we intend to explore whether ursolic acid (UA) can protect CMECs against hypoxia/reoxygenation (H/R) injury and to detect related molecular mechanism. Methods: CMECs w...

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Bibliographic Details
Main Authors: Bian, Z. (Author), Du, Y. (Author), Liu, H. (Author), Xu, F. (Author)
Format: Article
Language:English
Published: SAGE Publications Ltd 2022
Subjects:
Endothelial Cells
endothelium cell
genetics
human
Humans
hypoxia
Hypoxia
immunoglobulin enhancer binding protein
intercellular adhesion molecule 1
Intercellular adhesion molecule-1
Intercellular Adhesion Molecule-1
metabolism
migration
myeloid differentiation factor 88
Myeloid Differentiation Factor 88
NF-kappa B
oxidative stress
signal transduction
Signal Transduction
toll like receptor 4
Toll-Like Receptor 4
triterpene
Triterpenes
ursolic acid
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