Novel GREM1 variations in Sub-Saharan African patients with cleft lip and/or cleft palate

Objective: Cleft lip and/or cleft palate (CL/P) are congenital anomalies of the face and have multifactorial etiology, with both environmental and genetic risk factors playing crucial roles. Though at least 40 loci have attained genomewide significant association with nonsyndromic CL/P, these loci l...

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Main Authors:	Abdur-Rahman, L.O (Author), Adeyemo, A.A (Author), Adeyemo, W.L (Author), Agbenorku, P. (Author), Aregbesola, B.S (Author), Audu, R. (Author), Bello, S.A (Author), Busch, T.D (Author), Butali, A. (Author), Donkor, P. (Author), Eshete, M.A (Author), Gowans, L.J.J (Author), Marazita, M.L (Author), Mossey, P.A (Author), Murray, J.C (Author), Obiri-Yeboah, S. (Author), Oginni, F.O (Author), Ogunlewe, M.O (Author), Olaitan, P.B (Author), Onwuamah, C. (Author), Oseni, G. (Author), Oti, A.A (Author), Owais, A. (Author), Plange-Rhule, G. (Author)
Format:	Article
Language:	English
Published:	SAGE Publications Ltd 2018
Subjects:	3' untranslated region 5' untranslated region Africa south of the Sahara Africa South of the Sahara Article aspartic acid cheek cleft lip Cleft Lip Cleft lip and/or cleft palate cleft palate Cleft Palate controlled study DNA sequence DNA sequencing female Female gene gene locus genetic association genetic predisposition Genetic Predisposition to Disease genetic variation Genetic Variation genetics genome-wide association study Genome-Wide Association Study genotype Genotype glycine GREM1 gene GREM1 protein, human human Humans in vitro study Intercellular Signaling Peptides and Proteins major clinical study male Male mutation Mutation pedigree Pedigree phenotype Phenotype polymerase chain reaction Polymerase Chain Reaction Polymorphism, Single Nucleotide priority journal proline saliva Sanger sequencing serine signal peptide single nucleotide polymorphism Soft palate cleft Sub-Saharan Africans
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Novel GREM1 variations in Sub-Saharan African patients with cleft lip and/or cleft palate

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