ATG4A regulates human erythroid maturation and mitochondrial clearance

ATG4A regulates human erythroid maturation and mitochondrial clearance

Autophagy is a self-degradation pathway that is essential for erythropoiesis. During erythroid differentiation, autophagy facilitates the degradation of macromolecules and the programmed clearance of mitochondria. Impaired mitochondrial clearance results in anemia and alters the lifespan of red bloo...

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Bibliographic Details
Main Authors: Abkowitz, J.L (Author), Bergantinos, R. (Author), Clough, C.A (Author), Doulatov, S. (Author), Reilly, A. (Author), Stewart, S. (Author), Stolitenko, R. (Author), Stolla, M.C (Author), Thom, N. (Author), Wellington, R.C (Author)
Format: Article
Language:English
Published: American Society of Hematology 2022
Subjects:
article
autophagosome
autophagy (cellular)
controlled study
erythrocyte
erythroid cell
erythropoiesis
ex vivo study
genetic analysis
hematopoietic stem cell
human
human cell
human tissue
Key Points ATG4A regulates terminal erythroid maturation. ATG4A promotes autophagosome maturation and mitochondrial clearance
mitophagy
protein function
reticulocyte
upregulation
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