2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism

Background: Menopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety concerns with long-term treatment. We investigated the ability of 2′,3′,4′-trihydroxychalcone (2′,3′,4′-THC) to modulate estrogen receptor (ER)-media...

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Bibliographic Details
Main Authors: Chang, A. (Author), Cohen, I. (Author), Herber, C.B (Author), Leitman, D.C (Author), Wang, J.-C (Author), Yuan, C. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
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