WACS: improving ChIP-seq peak calling by optimally weighting controls

Background: Chromatin immunoprecipitation followed by high throughput sequencing (ChIP-seq), initially introduced more than a decade ago, is widely used by the scientific community to detect protein/DNA binding and histone modifications across the genome. Every experiment is prone to noise and bias,...

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Bibliographic Details
Main Authors:	Awdeh, A. (Author), Perkins, T.J (Author), Turcotte, M. (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2021
Subjects:	algorithm Algorithms article Background signals Bias ChIP-seq chromatin immunoprecipitation Chromatin immunoprecipitation Chromatin Immunoprecipitation chromatin immunoprecipitation sequencing Chromatin Immunoprecipitation Sequencing controlled study Controls DNA sequence high throughput sequencing High-Throughput Nucleotide Sequencing High-throughput sequencing histone modification Histone modification least square analysis Least squares regression noise Noise distribution reliability Reproducibilities reproducibility Reproducibility of Results Scientific community Sequence Analysis, DNA
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WACS: improving ChIP-seq peak calling by optimally weighting controls

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