Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach

Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach

Background: In this study, we demonstrate that our modified Gene Set Enrichment Analysis (GSEA) method, drug perturbation GSEA (dpGSEA), can detect phenotypically relevant drug targets through a unique transcriptomic enrichment that emphasizes biological directionality of drug-derived gene sets. Res...

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Bibliographic Details
Main Authors: Cameron, C.M (Author), Cameron, M.J (Author), Dazard, J.-E (Author), Fang, M. (Author), Richardson, B. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Antiviral therapy
biology
CD4+ T lymphocyte
CD4-Positive T-Lymphocytes
cell cycle
Cell Cycle
Computational Biology
Diagnosis
Differentially expressed gene
Drug discovery
drug effect
Drug Evaluation, Preclinical
Drug screening
Drug-targeting
Gene set enrichment analysis
Genes
genetics
human
Humans
metabolism
Mitochondrial dysfunction
Neuroendocrine tumors
Perturbation techniques
phenotype
Phenotype
preclinical study
probability
Probability
procedures
transcriptome
Transcriptome
Transcriptomics
Tumors
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