Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters

Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters

Background: A wide range of bioactive compounds is produced by enzymes and enzymatic complexes encoded in biosynthetic gene clusters (BGCs). These BGCs can be identified and functionally annotated based on their DNA sequence. Candidates for further research and development may be prioritized based o...

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Bibliographic Details
Main Authors: Almaas, E. (Author), Fossheim, F.A (Author), Sulheim, S. (Author), Wentzel, A. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
AntiSMASH
Automatic reconstruction
biological product
Biological Products
biosynthesis
Biosynthesis
Biosynthetic gene cluster
Biosynthetic gene clusters
Biosynthetic Pathways
Functional annotation
Gene knockout target
Genes
genetics
Genome scale metabolic model
Genome-scale metabolic model
Heterologous expression
Heterologous production
Metabolism
multigene family
Multigene Family
Natural products
Non-ribosomal peptide synthetases
Pipelines
Polyketide synthases
Research and development
Throughput
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