In silico drug repositioning based on the integration of chemical, genomic and pharmacological spaces

In silico drug repositioning based on the integration of chemical, genomic and pharmacological spaces

Background: Drug repositioning refers to the identification of new indications for existing drugs. Drug-based inference methods for drug repositioning apply some unique features of drugs for new indication prediction. Complementary information is provided by these different features. It is therefore...

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Bibliographic Details
Main Authors: Chen, H. (Author), Zhang, J. (Author), Zhang, Z. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
Algorithms
biology
Computational Biology
computer simulation
Computer Simulation
Databases, Factual
Disease associations
Drug feature
drug repositioning
Drug repositioning
Drug Repositioning
factual database
Forecasting
Genes
genomics
Genomics
Guilt by associations
Integration
Integration method
Leave-one-out cross validations
Prediction accuracy
Prediction performance
Similarity fusion
Similarity measurements
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