SomatoSim: precision simulation of somatic single nucleotide variants

SomatoSim: precision simulation of somatic single nucleotide variants

Background: Somatic single nucleotide variants have gained increased attention because of their role in cancer development and the widespread use of high-throughput sequencing techniques. The necessity to accurately identify these variants in sequencing data has led to a proliferation of somatic var...

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Bibliographic Details
Main Authors: Biesecker, L.G (Author), Hawari, M.A (Author), Hong, C.S (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
Algorithms
article
Benchmarking
Cancer development
Candidate positions
computer simulation
Computer Simulation
gene frequency
Genes
high throughput sequencing
High-Throughput Nucleotide Sequencing
High-throughput sequencing
mosaicism
Mosaicism
nucleotide
Nucleotides
Polymorphism, Single Nucleotide
Quality control
sequence alignment
Sequence alignments
simulation
Simulation
single nucleotide polymorphism
Single nucleotide variants
Single nucleotides
SNV
software
Software
Somatic variants
Three-stage process
User-friendly tool
Variant selection
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