The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

Background: Significant efforts have been made in building large-scale kinetic models of cellular metabolism in the past two decades. However, most kinetic models published to date, remain focused around central carbon pathways or are built around ad hoc reduced models without clear justification on...

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Bibliographic Details
Main Authors: Fengos, G. (Author), Hameri, T. (Author), Hatzimanikatis, V. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
Algorithms
article
biological model
Biological systems
Cell culture
Cellular metabolism
Complex networks
Escherichia coli
Flowcharting
genetics
Kinetic model
Kinetic modeling
kinetic parameters
Kinetic parameters
Kinetic theory
kinetics
Kinetics
Metabolic control analysis
metabolic engineering
Metabolic engineering
Metabolic Engineering
Metabolic flux distribution
Metabolic networks
Metabolic Networks and Pathways
Metabolic reconstruction
metabolic regulation
metabolism
Metabolism
Model complexity
Model reduction
Models, Biological
Network complexity
nonhuman
scale up
Sensitivity characteristics
Sensitivity coefficient
steady state
Stoichiometric models
stoichiometry
synthetic biology
Synthetic biology
workflow
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