A flexible ChIP-sequencing simulation toolkit

A flexible ChIP-sequencing simulation toolkit

Background: A major challenge in evaluating quantitative ChIP-seq analyses, such as peak calling and differential binding, is a lack of reliable ground truth data. Accurate simulation of ChIP-seq data can mitigate this challenge, but existing frameworks are either too cumbersome to apply genome-wide...

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Bibliographic Details
Main Authors: Goren, A. (Author), Gymrek, M. (Author), Lamkin, M. (Author), Qiu, Y. (Author), Ren, K. (Author), Zheng, A. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Analysis tools
article
benchmarking
Benchmarking
bioinformatics
Bioinformatics
C++ (programming language)
ChIP-sequencing
chromatin immunoprecipitation sequencing
Chromatin Immunoprecipitation Sequencing
Command line programs
Command-line program
computer simulation
Computer Simulation
Computer software
Differential binding
DNA sequence
epigenetics
Epigenomics
Experimental conditions
Experimental parameters
genome
Genome
Ground truth data
high throughput sequencing
High-Throughput Nucleotide Sequencing
Models, Statistical
Sequence Analysis, DNA
simulation
Simulation framework
Simulation tool
Simulation toolkits
software
Software
statistical model
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