ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

Background: ChIP-seq combines chromatin immunoprecipitation assays with sequencing and identifies genome-wide binding sites for DNA binding proteins. While many binding sites have strong ChIP-seq ‘peak’ observations and are well captured, there are still regions bound by proteins weakly, with a rela...

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Bibliographic Details
Main Authors: Chen, X. (Author), Clarke, R. (Author), Hilakivi-Clarke, L. (Author), Neuwald, A.F (Author), Shi, X. (Author), Xuan, J. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
article
Bayes theorem
Bayes Theorem
Bayesian integration
binding site
Binding sites
Binding Sites
chromatin immunoprecipitation
Chromatin Immunoprecipitation
Chromatin immunoprecipitation assay
chromatin immunoprecipitation sequencing
Control chips
DNA microarray
DNA sequence
DNA-binding protein
enhancer region
Gene encoding
Gene expression
Gene expression regulation
Genomic locations
high throughput sequencing
High-Throughput Nucleotide Sequencing
Oligonucleotide Array Sequence Analysis
Peak detection
promoter region
protein binding
Protein-binding sites
Proteins
Regulatory regions
Sequence Analysis, DNA
software
Software
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