Modeling transcriptional regulation using gene regulatory networks based on multi-omics data sources

Modeling transcriptional regulation using gene regulatory networks based on multi-omics data sources

Background: Transcriptional regulation is complex, requiring multiple cis (local) and trans acting mechanisms working in concert to drive gene expression, with disruption of these processes linked to multiple diseases. Previous computational attempts to understand the influence of regulatory mechani...

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Bibliographic Details
Main Authors: Bush, W.S (Author), Patel, N. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Cell culture
chromatin
Chromatin
Computational framework
Digital storage
Gene expression
gene expression regulation
Gene Expression Regulation
gene regulatory network
Gene regulatory network
Gene regulatory networks
Gene Regulatory Networks
genetics
information retrieval
Information Storage and Retrieval
Machine learning
metabolism
Multiple data types
Predictive analytics
Regulatory datum
Regulatory factors
Regulatory mechanism
Transcription
transcription factor
Transcription factor binding
Transcription factors
Transcription Factors
Transcriptional regulation
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