Predicting rifampicin resistance mutations in bacterial RNA polymerase subunit beta based on majority consensus

Predicting rifampicin resistance mutations in bacterial RNA polymerase subunit beta based on majority consensus

Background: Mutations in an enzyme target are one of the most common mechanisms whereby antibiotic resistance arises. Identification of the resistance mutations in bacteria is essential for understanding the structural basis of antibiotic resistance and design of new drugs. However, the traditionall...

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Bibliographic Details
Main Authors: Cheng, F. (Author), Ding, Q. (Author), Ning, Q. (Author), Wang, D. (Author), You, J. (Author), Zhong, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
antibiotic resistance
Antibiotic resistance
Antibiotics
Bacteria
bacterial RNA
bacterium
Bayes theorem
Bayes Theorem
Binding energy
Classification (of information)
Classifier
consensus
Consensus
Decision trees
DNA directed RNA polymerase
DNA-Directed RNA Polymerases
Drug Resistance, Bacterial
Experimental approaches
genetics
K-nearest neighbors
Labor intensive
Machine learning
mutation
Mutation
Nearest neighbor search
Prediction
Predictive performance
Probabilistic neural networks
Rapid identification
Resistance mutation
rifampicin
Rifampicin
Rifampin
RNA
RNA, Bacterial
Structural basis
Support vector machines
Turing machines
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