Simultaneous learning of individual microRNA-gene interactions and regulatory comodules

Simultaneous learning of individual microRNA-gene interactions and regulatory comodules

Background: MicroRNAs (miRNAs) function in post-transcriptional regulation of gene expression by binding to target messenger RNAs (mRNAs). Because of the key part that miRNAs play, understanding the correct regulatory role of miRNAs in diverse patho-physiological conditions is of great interest. Alt...

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Bibliographic Details
Main Authors: Chaterji, S. (Author), Jain, P. (Author), Koo, J. (Author), Roth, M. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Bioinformatics
Biological pathways
Biological significance
Clustering
Diseases
Factorization
Gene expression
gene expression profiling
Gene Expression Profiling
gene expression regulation
Gene Expression Regulation
Gene interactions
gene regulatory network
Gene Regulatory Networks
genetics
human
Humans
Matrix algebra
messenger RNA
microRNA
MicroRNAs
miRNA-gene interaction
Nonnegative matrix factorization
Optimization algorithms
Physiological condition
Post-transcriptional regulations
Regulatory comodules
RNA
RNA, Messenger
sequence analysis
Sequence Analysis, RNA
Target messengers
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