DR2S: an integrated algorithm providing reference-grade haplotype sequences from heterozygous samples

DR2S: an integrated algorithm providing reference-grade haplotype sequences from heterozygous samples

Background: High resolution HLA genotyping of donors and recipients is a crucially important prerequisite for haematopoetic stem-cell transplantation and relies heavily on the quality and completeness of immunogenetic reference sequence databases of allelic variation. Results: Here, we report on DR2...

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Bibliographic Details
Main Authors: Klasberg, S. (Author), Lange, V. (Author), Schmidt, A.H (Author), Schöfl, G. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
Algorithms
allele
Alleles
Allelic variation
article
Automated workflow
biologist
Database systems
Databases, Nucleic Acid
gene frequency
Genes
genotype
Genotype
haplotype
Haplotypes
heterozygosity
high throughput sequencing
High-Throughput Nucleotide Sequencing
HLA
HLA antigen
HLA Antigens
human
Integrated algorithm
KIR
nanopore sequencing
Next-generation sequencing
nucleic acid database
Phasing
quality control
Quality control
Reference sequencing
Sequence analysis
Sequence database
SMRT sequencing
Stem cell transplantation
Stem cells
Supporting tool
Third generation
Third-generation sequencing
workflow
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