CHIPIN: ChIP-seq inter-sample normalization based on signal invariance across transcriptionally constant genes

CHIPIN: ChIP-seq inter-sample normalization based on signal invariance across transcriptionally constant genes

Background: Multiple studies rely on ChIP-seq experiments to assess the effect of gene modulation and drug treatments on protein binding and chromatin structure. However, most methods commonly used for the normalization of ChIP-seq binding intensity signals across conditions, e.g., the normalization...

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Bibliographic Details
Main Authors: Boeva, V. (Author), Esposito, M. (Author), Gregoricchio, S. (Author), Guillouf, C. (Author), Kerdivel, G. (Author), Polit, L. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Algorithm
Binding intensity
Biochemistry
ChIP-seq
chromatin
Chromatin
chromatin immunoprecipitation
Chromatin Immunoprecipitation
Chromatin Immunoprecipitation Sequencing
Chromatin structure
Correction factors
Density profiles
DNA sequence
Expression levels
Gene expression
Gene Expression Data
Normalization
Open chromatin
protein binding
Protein binding
Protein Binding
R package
Regulatory regions
Sequence Analysis, DNA
Signal normalization
Signal to noise ratio
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