A novel automated image analysis pipeline for quantifying morphological changes to the endoplasmic reticulum in cultured human cells

A novel automated image analysis pipeline for quantifying morphological changes to the endoplasmic reticulum in cultured human cells

Background: In mammalian cells the endoplasmic reticulum (ER) comprises a highly complex reticular morphology that is spread throughout the cytoplasm. This organelle is of particular interest to biologists, as its dysfunction is associated with numerous diseases, which often manifest themselves as c...

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Bibliographic Details
Main Authors: Garcia-Pardo, M.E (Author), O’Sullivan, N.C (Author), Simpson, J.C (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
animal
Animals
Automated image analysis
Automation
Cell culture
cell line
Cell Line
Cell proliferation
Cells
Chemical analysis
Chemical perturbations
Complex networks
Diagnosis
endoplasmic reticulum
Endoplasmic reticulum
Endoplasmic Reticulum
Endoplasmic reticulum morphology
ER function
High-content imaging
High-content screening
human
Humans
Image analysis
Image analysis method
Image analysis software
image processing
Image Processing, Computer-Assisted
Mammals
Methodological approach
Morphological changes
Morphology
Pipelines
software
Software
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Internet

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