Conifer: clonal tree inference for tumor heterogeneity with single-cell and bulk sequencing data

Conifer: clonal tree inference for tumor heterogeneity with single-cell and bulk sequencing data

Background: Genetic heterogeneity of a cancer tumor that develops during clonal evolution is one of the reasons for cancer treatment failure, by increasing the chance of drug resistance. Clones are cell populations with different genotypes, resulting from differences in somatic mutations that occur...

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Bibliographic Details
Main Authors: Baghaarabani, L. (Author), Foroughmand-Araabi, M.-H (Author), Goliaei, B. (Author), Goliaei, S. (Author), Shariatpanahi, S.P (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Bayesian nonparametric model
Bulk sequencing
Cancer development
Cell culture
Cell populations
Cell proliferation
clonal evolution
Clonal Evolution
Clonal tree
Cloning
Diseases
Evolutionary history
Evolutionary relationships
Evolutionary tree
Forestry
Genes
Genetic heterogeneities
genetics
genotype
Genotype
Heterogeneity of tumor
human
Humans
mutation
Mutation
neoplasm
Neoplasms
single cell analysis
Single-Cell Analysis
Single-cell sequencing
Tracheophyta
Treatment failure
Trees (mathematics)
Tumor heterogeneity
Tumors
vascular plant
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