The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma

The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma

Background: Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor with grim prognosis. Aberrant DNA methylation is an epigenetic mechanism that promotes GBM carcinogenesis, while the function of DNA methylation at enhancer regions in GBM remains poorly describ...

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Bibliographic Details
Main Authors: Ji, J. (Author), Li, D. (Author), Wang, R. (Author), Wang, S. (Author), Yu, Q. (Author), Zhao, X. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Alkylation
Biomarker
Biomarkers, Tumor
Brain Neoplasms
brain tumor
Diagnosis
DNA methylation
DNA Methylation
Enhancer region
Epigenetic mechanisms
Epigenetic regulation
Functional enrichment analysis
gene expression
Gene expression
Gene Expression
gene expression regulation
Gene Expression Regulation, Neoplastic
gene regulatory network
Gene Regulatory Networks
genetics
glioblastoma
Glioblastoma
Glioblastoma multiforme
human
Humans
Methylation
Regulatory network
Regulatory patterns
Small-molecule drugs
Target gene expression
tumor marker
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