Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA

Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA

Background: The liver plays a major role in the metabolic activation of xenobiotics (drugs, chemicals such as pollutants, pesticides, food additives..). Among environmental contaminants of concern, heterocyclic aromatic amines (HAA) are xenobiotics classified by IARC as possible or probable carcinog...

Full description

Bibliographic Details
Main Authors: Conan, M. (Author), Langouet, S. (Author), Siegel, A. (Author), Théret, N. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Additives
amine
Amines
Bayes theorem
Bayes Theorem
Bayesian frameworks
Biochemistry
Biomolecules
carcinogen
Carcinogens
Chemical activation
Chemical contamination
DNA
DNA adduct
DNA Adducts
DNA binding ability
Environmental contaminant
Enzymes
Filtering procedures
Forecasting
Heterocyclic aromatic amines
human
Humans
Metabolic activation
Metabolism
Metabolites
Pipelines
Prediction tools
Predictive analytics
Reaction prediction
Site of metabolism
Systems biology
xenobiotic agent
Xenobiotics
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items