adabmDCA: adaptive Boltzmann machine learning for biological sequences

Background: Boltzmann machines are energy-based models that have been shown to provide an accurate statistical description of domains of evolutionary-related protein and RNA families. They are parametrized in terms of local biases accounting for residue conservation, and pairwise terms to model epis...

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Bibliographic Details
Main Authors: Muntoni, A.P (Author), Pagnani, A. (Author), Weigt, M. (Author), Zamponi, F. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
RNA
Online Access:View Fulltext in Publisher