Filling gaps of genome scaffolds via probabilistic searching optical maps against assembly graph

Filling gaps of genome scaffolds via probabilistic searching optical maps against assembly graph

Background: Optical maps record locations of specific enzyme recognition sites within long genome fragments. This long-distance information enables aligning genome assembly contigs onto optical maps and ordering contigs into scaffolds. The generated scaffolds, however, often contain a large amount o...

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Bibliographic Details
Main Authors: Bu, D. (Author), Huang, B. (Author), Ju, F. (Author), Shi, Z. (Author), Sun, S. (Author), Wang, B. (Author), Wei, G. (Author), Zhong, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
Algorithms
Bayes theorem
Bayes Theorem
contig mapping
Contig Mapping
Contigs
DNA sequence
Enzyme recognition
Evaluation strategies
Filling
Filling gaps
Gap filling
Genes
genome
Genome
Genome assembly
Optical maps
Probabilistic search
Probabilistics
restriction mapping
Restriction Mapping
Scaffolding
Scaffolds
Sequence Analysis, DNA
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