GSA: an independent development algorithm for calling copy number and detecting homologous recombination deficiency (HRD) from target capture sequencing

GSA: an independent development algorithm for calling copy number and detecting homologous recombination deficiency (HRD) from target capture sequencing

Background: The gain or loss of large chromosomal regions or even whole chromosomes is termed as genomic scarring and can be observed as copy number variations resulting from the failure of DNA damage repair. Results: In this study, a new algorithm called genomic scar analysis (GSA) has developed an...

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Bibliographic Details
Main Authors: Cai, Y. (Author), Chen, D. (Author), Li, Q. (Author), Meng, P. (Author), Shao, M. (Author), Shi, T. (Author), Song, C. (Author), Wang, C. (Author), Wang, X. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
Algorithms
Analysis algorithms
Cell culture
Cicatrix
copy number variation
Copy number variations
DNA Copy Number Variations
Genes
Genomic scar analyse
Genomic scar analysis
genomics
Genomics
homologous recombination
Homologous recombination
Homologous Recombination
Homologous recombination deficiency
human
Humans
Pathway genes
scar
Segmentation
Tumor purity and ploidy correction
Tumor samples
Tumors
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