Exploring the associations between transcript levels and fluxes in constraint-based models of metabolism

Exploring the associations between transcript levels and fluxes in constraint-based models of metabolism

Background: Several computational methods have been developed that integrate transcriptomics data with genome-scale metabolic reconstructions to increase accuracy of inferences of intracellular metabolic flux distributions. Even though existing methods use transcript abundances as a proxy for enzyme...

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Bibliographic Details
Main Authors: Hooiveld, G.J.E.J (Author), Keijer, J. (Author), Martins dos Santos, V.A.P (Author), Sinha, N. (Author), Suarez-Diez, M. (Author), van Schothorst, E.M (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
article
Biochemical Phenomena
biochemistry
biological model
Constraint-based modeling
Constraint-based models
Constraints-based modeling
E-flux
E-Flux
Enzyme activity
Escherichia coli
extraction
Gene expression
Gene expression integration
Genes expression
genetics
Metabolic flux distribution
Metabolic Networks and Pathways
Metabolic reconstruction
metabolism
Metabolism
Models, Biological
nonhuman
prediction
Proportionality constant
Saccharomyces cerevisiae
Transcript level
transcriptome
Transcriptome
transcriptomics
Transcriptomics
Yeast
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