Investigating treatment-effect modification by a continuous covariate in IPD meta-analysis: an approach using fractional polynomials
Background: In clinical trials, there is considerable interest in investigating whether a treatment effect is similar in all patients, or that one or more prognostic variables indicate a differential response to treatment. To examine this, a continuous predictor is usually categorised into groups ac...
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd
2022
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| Online Access: | View Fulltext in Publisher |