Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines

Background: Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and its mechanism of action remains unknown. The ability of cytokine-related apopt...

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Bibliographic Details
Main Authors:	Ahmad, U. (Author), Eshak, Z. (Author), Ideris, A. (Author), Othman, F. (Author), Raihan, J. (Author), Yong, Y.K (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2019
Subjects:	4 T1 cells 4T1 cell line af 2240 AF2240 alanine aminotransferase allotransplantation animal animal cell animal experiment animal model animal tissue Animals antineoplastic activity Antineoplastic Agents, Hormonal antineoplastic hormone agonists and antagonists apoptosis Apoptosis Article aspartate aminotransferase Bagg albino mouse bilirubin body weight breast cancer Breast cancer Breast Neoplasms breast tumor cancer inhibition cancer mortality cancer regression cell culture technique Cell Culture Techniques cell isolation Cell Line, Tumor chick embryo Chick Embryo controlled study cytokine cytokine production Cytokines cytometry disease model Disease Models, Animal down regulation drug effect drug mechanism embryo enzyme linked immunosorbent assay enzyme linked immunospot assay female Female gamma interferon human Humans immunology interleukin 10 interleukin 12p70 interleukin 6 liver function test metabolism Mice Mice, Inbred BALB C monocyte chemotactic protein 1 mortality rate mouse Newcastle disease virus Newcastle disease virus AF2240 nonhuman oncolytic virotherapy Oncolytic Virotherapy oncolytic virus Oncolytic Viruses procedures spleen cell tamoxifen Tamoxifen transplantation treatment outcome Treatment Outcome tumor cell line tumor necrosis factor tumor weight tumor xenograft upregulation virus strain
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Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines

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