Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231

Background: Several compounds isolated from Dryobalanops have been reported to exhibit cytotoxic effects to several cancer cell lines. This study investigated the cytotoxic effects, cell cycle arrest and mode of cell death in ampelopsin E-treated triple negative cells, MDA-MB-231. Methods: Cytotoxic...

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Bibliographic Details
Main Authors:	Ahmat, N. (Author), Fakurazi, S. (Author), Foo, J.B (Author), Ong, Y.S (Author), Rahman, N.A (Author), Razali, Z.A (Author), Tor, Y.S (Author), Wibowo, A. (Author), Yazan, L.S (Author), Yeap, S.K (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2016
Subjects:	3T3 cell line ampelopsin ampelopsin E Ampelopsin E ampelopsin F animal cell apoptosis Apoptosis Article breast cancer cell line Cell cycle arrest cell cycle checkpoint Cell Cycle Checkpoints cell damage Cell Line, Tumor cell membrane cell viability chemistry colon cancer concentration response controlled study cytotoxic agent Cytotoxicity Dipterocarpaceae doxorubicin drug cytotoxicity drug effects Dryobalanops Dryobalanops extract Dryobalanops sp embryo cell fibroblast flavonoid Flavonoids flexuosol A flow cytometry G2 phase cell cycle checkpoint HeLa cell line HT 29 cell line human human cell Humans IC50 laevifonol lipocortin 5 lung alveolus cell carcinoma M phase cell cycle checkpoint malaysianol A malaysianol D MCF 7 cell line MDA MB 231 cell membrane damage metabolism mouse MTT assay nepalensinol E nonhuman plant extract Plant Extracts tamoxifen triple negative breast cancer Triple Negative Breast Neoplasms tumor cell line unclassified drug
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Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231

Internet

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