Antinociception of petroleum ether fraction derived from crude methanol extract of Melastoma malabathricum leaves and its possible mechanisms of action in animal models

Antinociception of petroleum ether fraction derived from crude methanol extract of Melastoma malabathricum leaves and its possible mechanisms of action in animal models

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Background: Melastoma malabathricum L. (family Melastomaceae) has been traditionally used as remedies against various ailments including those related to pain. The methanol extract of M. malabathricum leaves has been proven to show antinociceptive activity. Thus, the present study aimed to determine...

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Bibliographic Details
Main Authors: Abd. Rahman, S. (Author), Ching, S.M (Author), Deny, S. (Author), Hamid, S.S.A (Author), Jaios, E.S (Author), Omar, M.H (Author), Salleh, M.Z (Author), Taher, M. (Author), Teh, L.K (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Published: BioMed Central Ltd. 2016
Subjects:
acetic acid ethyl ester
acetylsalicylic acid
alkane
Alkanes
analgesic agent
Analgesics
animal
animal experiment
animal model
Animals
antagonists and inhibitors
antinociception
Antinociceptive activity
antinociceptive agent
arginine
Article
central nervous system
chemical composition
chemistry
Chromatography, High Pressure Liquid
controlled study
Crude methanol extract
cyclic GMP
disease model
Disease Models, Animal
dose response
drug dose comparison
drug screening
epigallocatechin
Fraction
fractionation
gallocatechin
Gas Chromatography-Mass Spectrometry
glutamatergic system
Glutamatergic system
glutamic acid
high performance liquid chromatography
hot plate test
Institute for Cancer Research mouse
isolation and purification
male
Male
mass fragmentography
Mechanisms of antinociception
Melastoma malabathricum
Melastoma malabathricum extract
Melastomataceae
methanol
Methanol
methylene blue
Mice
Mice, Inbred ICR
morphine sulfate
mouse
n(g) nitroarginine methyl ester
naloxone
naphtha
nitric oxide
NO-mediated/cGMP-independent pathway
nonhuman
Non-opioid system
opiate receptor
pain
Pain
palmitic acid
petroleum ether
Phytochemicals
plant extract
Plant Extracts
plant leaf
Plant Leaves
plant medicinal product
rat
Rats
Rats, Sprague-Dawley
saponin
single drug dose
solvent
Solvents
Sprague Dawley rat
tannin derivative
toxicity
toxicity testing
triterpene
TRPV Cation Channels
ultra performance liquid chromatography
unclassified drug
vanilloid receptor
vanilloid receptor 1
Vanilloid receptors
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