Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats

Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats

Background: Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an attempt to develop a pharmaceutical product with antiulcer potential, the synergistic gastroprotective act...

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Bibliographic Details
Main Authors: Abdullah, M.N.H (Author), Halim, S.Z (Author), Mohtarrudin, N. (Author), Omar, M.H (Author), Wahab, I.R.A (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Published: BioMed Central Ltd. 2017
Subjects:
animal
animal experiment
animal tissue
Animals
antioxidant
Antioxidant
antioxidant activity
Antioxidants
Antisecretory
antiulcer activity
antiulcer agent
Anti-Ulcer Agents
Article
catalase
chemistry
controlled study
DPPH radical scavenging assay
drug effects
drug efficacy
drug mixture
drug potentiation
Elaeocarpaceae
enzyme activity
Gastric Juice
Gastric ulcer
glutathione
IC50
male
Male
malonaldehyde
Melastoma malabathricum
Melastoma malabathricum extract
Melastomataceae
methanol
Muntingia calabura
Muntingia calabura extract
nonhuman
oxygen radical absorbance capacity
pathology
plant extract
Plant Extracts
plant leaf
Plant Leaves
prostaglandin E2
pylorus ligation
ranitidine
rat
Rats
Rats, Sprague-Dawley
Sprague Dawley rat
stomach
Stomach
stomach juice
stomach mucus
stomach pH
stomach protection
stomach secretion
stomach ulcer
Stomach Ulcer
superoxide dismutase
Synergistic effect
ultra performance liquid chromatography
unclassified drug
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