Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L

Background: Morinda citrifolia L. that was reported with immunomodulating and cytotoxic effects has been traditionally used to treat multiple illnesses including cancer. An anthraquinone derived from fruits of Morinda citrifolia L., nordamnacanthal, is a promising agent possessing several in vitro b...

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Bibliographic Details
Main Authors:	Abu, N. (Author), Alitheen, N.B (Author), Ismail, N.H (Author), Mohamad, N.E (Author), Nordin, N. (Author), Rasol, N.E (Author), Romli, M.F (Author), Subramani, T. (Author), Yeap, S.K (Author), Zamberi, N.R (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2018
Subjects:	4T1 4T1 cell line aldehyde Aldehydes animal animal cell animal experiment animal model animal tissue Animals anthraquinone anthraquinone derivative Anthraquinones antineoplastic activity antineoplastic agent Antineoplastic Agents antiproliferative activity apoptosis Apoptosis Article Bagg albino mouse breast cancer Breast cancer Breast Neoplasms breast tumor cancer inhibition cell cycle assay cell death Cell Line, Tumor chemistry chronic toxicity controlled study cytotoxicity assay drug cytotoxicity drug effects drug mechanism drug megadose drug screening drug structure female Female human human cell Humans immunologic factor Immunologic Factors immunomodulation Immunomodulation immunophenotyping immunoregulation in vitro study in vivo study lipocortin 5 low drug dose male Male MCF-7 cell line MCF-7 Cells MDA-MB-231-BR cell line metabolism Mice Mice, Inbred BALB C Morinda Morinda citrifolia Morinda citrifolia extract morning dosage mouse MTT assay nonhuman nordamnacanthal Nordamnacanthal plant extract Plant Extracts plant stem spleen toxicity testing Toxicity Tests, Subchronic treatment outcome tumor cell line tumor immunity tumor volume unclassified drug YAC-1 cell line
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Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L

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