$Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway$

Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

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Background: Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-independent pathway. In the present study, MECN was sequentially partitioned to o...

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Bibliographic Details
Main Authors:	Abdul Kadir, A. (Author), Abdul Rahim, M.H (Author), Ahmed, Q.U (Author), Ching, S.M (Author), Mohd Sani, M.H (Author), Omar, M.H (Author), Zakaria, Z.A (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2019
Subjects:	1h [1, 2, 4]oxadiazolo[4,3 a]quinoxalin 1 one abdominal constriction abdominal disease Acanthaceae acetic acid adult alkane Alkanes analgesic agent Analgesics animal animal experiment animal model Animals antinociception Antinociceptive arginine arginine nitric oxide cyclic guanosine monophosphate signaling pathway Article beta funaltrexamine chemistry cinnamic acid Clinacanthus nutans Clinacanthus nutans extract Clinacanthus nutans; Acanthaceae clinical assessment tool combination chemotherapy controlled study cyclic GMP Cyclic GMP dose response drug effect drug megadose drug protein binding drug screening drug synthesis flavonoid formaldehyde guanylate cyclase inhibitor high performance liquid chromatography hot plate test Institute for Cancer Research mouse locomotion male Male Mechanisms of action metabolism methanol Mice Mice, Inbred ICR monotherapy mouse naltrindole naphtha nitric oxide Nitric Oxide nociception NO-mediated/cGMP-independent pathway; phenolic compounds nonhuman norbinaltorphimine opiate receptor Opioid receptors paw licking test petroleum ether phytochemistry plant extract Plant Extracts plant leaf Plant Leaves Receptors, Opioid rota rod assay saponin derivative signal transduction Signal Transduction steroid triterpene derivative unclassified drug
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Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

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