Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

Introduction: Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activities, and phytoconstituents of lipid-soluble (chloroform) extract of D. li...

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Main Authors:	Abdullah, M.N.H (Author), Azizah, R. (Author), Azmi, A.H (Author), Balan, T. (Author), Nur Zainol, A.S (Author), Omar, M.H (Author), Sahmat, A. (Author), Sulistyorini, L. (Author), Zakaria, Z.A (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2021
Series:	BMC Complementary Medicine and Therapies
Subjects:	Acetaminophen adult alanine aminotransferase alcohol alkaline phosphatase animal animal experiment animal model animal tissue Animals antioxidant activity antioxidant assay Article aspartate aminotransferase catalase Chemical and Drug Induced Liver Injury chemistry chloroform Chloroform Chloroform extract Dicranopteris linearis Dicranopteris linearis extract DPPH radical scavenging assay drug effect electrospray mass spectrometry Endogenous enzymatic antioxidant system enzyme linked immunosorbent assay experimental hepatotoxicity flavonoid glutathione peroxidase Hepatoprotective activity Hesperetin histopathology hydroxybenzoic acid derivative hydroxycinammate IC50 lipid solubility liquid chromatography-mass spectrometry liver Liver liver homogenate liver protection male Male malonaldehyde metabolism nonhuman ORAC assay oxidative stress Oxidative Stress paracetamol paracetamol induced liver intoxication Paracetamol intoxication pathology phytochemistry plant extract Plant Extracts plant leaf Plant Leaves polyphenol Polyphenols rat Rats Rats, Sprague-Dawley reactive oxygen metabolite Sprague Dawley rat superoxide dismutase tannin toxic hepatitis Tracheophyta triterpene Triterpenes unclassified drug vascular plant
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Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

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