A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

Background: With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing efficacy. Methods: We report an mRNA-based vaccine using an engineered “hybrid” rec...

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Bibliographic Details
Main Authors: Chang, C.-S (Author), Chang, Y.-W (Author), Chen, H.-F (Author), Chen, L.-Y (Author), Chen, T.-Y (Author), Chen, W.-Y (Author), Cheng, C.-M (Author), Chiang, M.-T (Author), Chiang, P.-C (Author), Chiu, C.-W (Author), Chou, Y.-C (Author), Chuang, C.-Y (Author), Hong, M.-H (Author), Hsieh, C.-H (Author), Hsu, F.-F (Author), Hsu, S.-T (Author), Ko, H.-Y (Author), Ko, Y.-A (Author), Kumari, M. (Author), Lan, Y.-H (Author), Lee, C.-C (Author), Lee, I.-J (Author), Liang, J.-J (Author), Liao, C.-C (Author), Liao, H.-N (Author), Lin, C.-C (Author), Lin, H.-T (Author), Lin, Y.-L (Author), Lin, Y.-S (Author), Liu, W.-C (Author), Ma, H.-H (Author), Sun, C.-P (Author), Tao, M.-H (Author), Tseng, S.-C (Author), Tsung, S.-I (Author), Wang, I.-H (Author), Wu, H.-C (Author), Wu, P.-Y (Author), Yang, T.-J (Author), Yu, P.-Y (Author), Yuan, J.P.-Y (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Booster dose
COVID-19
Cross-protectivity
Hybrid vaccine
mRNA vaccine
Next generation vaccine
Omicron vaccine
SARS-CoV-2
Variants of concern
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