PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model

PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model

Background: Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal lung disease. In addition to dense fibrous tissue, abnormal angiogenesis is also an important feature of IPF. Pigment epithelium-derived factor (PEDF) is an angiogenesis inhibitor and a potential anti-fibrous factor....

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Bibliographic Details
Main Authors: Chao, Z. (Author), Chen, J. (Author), Dong, H. (Author), Jia, C. (Author), Liang, J. (Author), Liu, X. (Author), Liu, Z. (Author), Qin, H. (Author), Qin, X. (Author), Yuan, Y. (Author), Zhang, H. (Author), Zhang, Z. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
animal
Animals
bleomycin
Bleomycin
C57BL mouse
eye protein
Eye Proteins
fibroblast
Fibroblast
Fibroblasts
fibrosing alveolitis
fibrosis
Fibrosis
Idiopathic Pulmonary Fibrosis
IPF
lung
Lung
metabolism
Mice
Mice, Inbred C57BL
mouse
nerve growth factor
Nerve Growth Factors
PEDF
peroxisome proliferator activated receptor
Peroxisome Proliferator-Activated Receptors
pigment epithelium-derived factor
PPAR-γ
rat
Rats
serine proteinase inhibitor
Serpins
transforming growth factor beta1
Transforming Growth Factor beta1
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