A single point mutation in the Plasmodium falciparum 3′–5′ exonuclease does not alter piperaquine susceptibility

A single point mutation in the Plasmodium falciparum 3′–5′ exonuclease does not alter piperaquine susceptibility

Background: The rise in Plasmodium falciparum resistance to dihydroartemisinin–piperaquine (DHA–PPQ) treatment has been documented in the Greater Mekong Subregion with associations with mutations in the P. falciparum chloroquine resistance transporter (pfcrt) and plasmepsin 2 (pfpm2) genes. However,...

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Bibliographic Details
Main Authors: Boonyalai, N. (Author), Griesenbeck, J.S (Author), Kirativanich, K. (Author), Praditpol, C. (Author), Thamnurak, C. (Author), Vesely, B.A (Author), Waters, N.C (Author), Wojnarski, M. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
animal
Animals
antimalarial agent
Antimalarials
carrier protein
chloroquine
Chloroquine
copy number variation
DNA Copy Number Variations
drug resistance
Drug Resistance
exonuclease
Exonuclease
Exonucleases
Gene editing
genetics
Malaria
malaria falciparum
Malaria, Falciparum
Membrane Transport Proteins
metabolism
mutation
Mutation
parasite
Parasites
parasitology
phosphodiesterase I
Phosphodiesterase I
piperaquine
Piperaquine resistance
piperazine derivative
Piperazines
Plasmodium falciparum
point mutation
Point Mutation
protozoal protein
Protozoan Proteins
quinoline derivative
Quinolines
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