A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer

Background: miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-346 on DNA damage, and its potential as a therapeutic agent. Methods: RNA-IP, RN...

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Main Authors:	Bevan, C.L (Author), Bogdan, D. (Author), Bristow, R. (Author), Bryant, R.J (Author), Constantin, T.A (Author), Cyran, O.W (Author), de Bono, J. (Author), Deng, L. (Author), Dobbs, F.M (Author), Feng, F.Y (Author), Figueiredo, I. (Author), Fletcher, C.E (Author), Gurel, B. (Author), Hester, J. (Author), Issa, F. (Author), Knudsen, K. (Author), Kudo, H. (Author), Leach, D.A (Author), Liu, Y. (Author), Lorentzen, M.P.G.S (Author), Mills, I.G (Author), Neeb, A. (Author), Orafidiya, F. (Author), Parkes, E. (Author), Pereira, R.R (Author), Philippou, Y. (Author), Reed, S.H (Author), Varela-Carver, A. (Author), Yuan, W. (Author), Zhao, S.G (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2022
Subjects:	animal experiment animal model animal tissue Article binding site bioinformatics biotinylation cancer cancer survival cell cycle Cell Cycle cell cycle arrest cell cycle progression controlled study DNA damage DNA Damage down regulation gene amplification gene mapping genetics hepatocyte nuclear factor 3alpha human human cell Humans Long non-coding RNA long untranslated RNA male Male metabolism microRNA MicroRNAs MIRN346 microRNA, human mouse Myc protein Non-coding RNA nonhuman prostate cancer Prostate cancer prostate tumor Prostatic Neoplasms PUM2 protein, human Replication stress RNA binding protein RNA sequence RNA, Long Noncoding RNA-Binding Proteins Target-directed microRNA decay transcription factor transcription factor HOXB13 transcription factor NKX3.1 Transcription Factors unclassified drug untranslated RNA
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A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer

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