Nanozyme-natural enzymes cascade catalyze cholesterol consumption and reverse cancer multidrug resistance

Nanozyme-natural enzymes cascade catalyze cholesterol consumption and reverse cancer multidrug resistance

Multidrug resistance is still a major obstacle to cancer treatment. The most studies are to inhibit the activity of the drug transporter P-glycoprotein (P-gp), but the effect is not ideal. Herein, a nanosystem was built based on cascade catalytic consumption of cholesterol. Cholesterol oxidase (natu...

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Bibliographic Details
Main Authors: Bai, Y. (Author), Du, B. (Author), Huang, J. (Author), Jiao, Q. (Author), Ma, H. (Author), Zhao, M. (Author), Zheng, M. (Author), Zhou, J. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Amides
Apoptosis
Catalyse
Cell death
Cholesterol
Cholesterol oxidase
Chondroitin sulfate
Chondroitinsulfate
Diseases
Drug-resistance
Enzyme cascades
Fluidity
Glycoproteins
Lipid raft
Multidrug resistance
Natural enzyme
P-glycoprotein
Reverse drug resistance
Sulfur compounds
Tumors
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