miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia–reperfusion injury in steatotic grafts

miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia–reperfusion injury in steatotic grafts

Background: Steatotic livers tolerate ischemia–reperfusion injury (IRI) poorly, increasing the risk of organ dysfunction. Ferroptosis is considered the initiating factor of organ IRI. Heme oxygenase oxygen-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) (HO-1/BMMSCs) can reduce hepatic...

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Bibliographic Details
Main Authors: Li, X. (Author), Song, H. (Author), Tian, X. (Author), Wu, L. (Author), Yuan, M. (Author), Zheng, W. (Author), Zuo, H. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
animal
Animals
Bone
Bone marrow mesenchymal
Bone marrow mesenchymal stem cell
Bone marrow mesenchymal stem cells
Cell culture
exosome
Exosomes
ferroptosis
Ferroptosis
genetics
heme oxygenase 1
Heme oxygenase oxygen-1
Heme Oxygenase-1
Heme oxygenases
human
Humans
Ischemia-reperfusion injury
Ischemia–reperfusion injury
liver transplantation
Liver transplantation
Liver Transplantation
living donor
Living Donors
male
Male
Marrow mesenchymal stem cells
mesenchymal stem cell
Mesenchymal Stem Cells
metabolism
microRNA
MicroRNAs
miR-124-3p
Mir-124-3p
MIRN124 microRNA, human
MIRN124 microRNA, rat
Oxygen
Porphyrins
rat
Rats
reperfusion injury
Reperfusion Injury
RNA
Six transmembrane epithelial antigen 3
STEAP3
Stem cells
Transmembranes
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