Lipid-coated albumin-paclitaxel nanoparticles loaded with sorcin-siRNA reverse cancer chemoresistance via restoring intracellular calcium ion homeostasis

Lipid-coated albumin-paclitaxel nanoparticles loaded with sorcin-siRNA reverse cancer chemoresistance via restoring intracellular calcium ion homeostasis

Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpressed in many chemoresistant cancer cells, including paclitaxel (PTX)-resistant ovarian cancer...

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Bibliographic Details
Main Authors: Dou, H. (Author), Gao, X. (Author), Guan, W. (Author), Li, X. (Author), Wang, C. (Author), Wang, F. (Author), Xiong, S. (Author), Xu, G. (Author), Xu, X. (Author), Yuan, J. (Author), Zhang, P. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Calcium
Calcium ion homeostasis
Cancer cells
Cell death
Chemoresistance
Chemotherapy
Controlled drug delivery
Diseases
Drug resistance
Drug-resistance
Intracellular calcium
Ions
Malignant tumor
Malignant tumors
Nanoparticle
Nanoparticles
Paclitaxel
Proteins
Reversal
Targeted drug delivery
TGF-β
TGF-β signaling
Tumors
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