Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade

Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade

Metastasis is one of the main causes of failure in the treatment of triple-negative breast cancer (TNBC). Abnormally estrogen level and activated platelets are the key driving forces for TNBC metastasis. Herein, an “ion/gas” bioactive nanogenerator (termed as IGBN), comprising a copper-based MOF and...

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Bibliographic Details
Main Authors: Guo, X. (Author), Jiang, W. (Author), Li, Y. (Author), Liu, J. (Author), Liu, W. (Author), Shi, J. (Author), Si, P. (Author), Wang, S. (Author), Xiang, T. (Author), Yin, N. (Author), Zhang, K. (Author), Zhang, Z. (Author), Zhao, X. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Estrogen regulation
Ion/gas therapy
Metastasis-promoting microenvironment
Platelets blockade
Triple-negative breast cancer
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