IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the Caspase-1/ IL-1 ß pathway

IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the Caspase-1/ IL-1 ß pathway

Aims and background: IFI16 plays an important role in innate immunity against invasive microbial infection by sensing double-stranded DNA viruses due to caspase-1-dependent inflammasome activation and subsequent maturation and secretion of IL-1β. However, the role of IFI16 in regulating the immune r...

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Bibliographic Details
Main Authors: Du, W. (Author), Guo, Y. (Author), Li, C. (Author), Li, Q. (Author), Liu, L. (Author), Liu, X. (Author), Xie, S. (Author), Zhao, X. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Caspase 1
Caspase-1
complication
female
Female
genetics
glomerulonephritis
Glomerulonephritis
HBV-DNA
HBV-GN
HEK293 cell line
HEK293 Cells
hepatitis B
Hepatitis B
Hepatitis B virus
human
Humans
IFI16
IFI16 protein, human
IL-1β
inflammation
Inflammation
interleukin 1beta converting enzyme
male
Male
metabolism
nuclear protein
Nuclear Proteins
phosphoprotein
Phosphoproteins
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